Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan
Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan
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DOI：
10.1111/j.1365-2036.2007.03350.x
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发表时间：
2007-07-01
影响因子：
7.6
通讯作者：
Kinoshita, Y.
中科院分区：
文献类型：
--
作者：
Miwa, H.;Sasaki, M.;Kinoshita, Y.
在日本，很少有研究比较质子泵抑制剂在缓解非糜烂性反流病（NERD）和糜烂性胃食管反流病（GERD）症状方面的疗效。方法采用改良洛杉矶分级法对GERD患者进行内镜分级，伴有烧心（N级和M级：NERD，A级和B级：轻度反流性食管炎（RO），C级和D级：重度RO）。结果NERD组和糜烂型GERD组症状完全缓解率分别为35.8%和55.4%，其中轻度RO为51.1%，重度RO为77.8%。与NERD患者相比，Rabbadine对糜烂性GERD患者的疗效显著更好。在NERD亚组（N级和M级），症状改善无差异observed.Conclusions四周，雷贝拉唑10 mg/天抑酸治疗是有效的，在日本GERD患者的症状解决。这种疗法在糜烂性GERD患者中比在NERD患者中更有效，在重度RO患者中比轻度RO患者更有效。
Background Few studies have compared the efficacy of proton pump inhibitors in resolving the symptoms of non-erosive reflux disease (NERD) and of erosive gastro-oesophageal reflux disease (GERD) in Japan.Aim To investigate and compare the efficacy of 4-week course of rabeprazole 10 mg/day on symptom resolution in NERD and erosive GERD in Japan.Method The modified Los Angeles classification was used to grade endoscopically GERD in patients with heartburn (Grades N and M: NERD, Grades A and B: mild reflux oesophagitis (RO), and Grades C and D: severe RO). Rabeprazole 10 mg/day was administered for 4 weeks to 180 patients who kept symptom diaries.Reuslts Complete relief of the symptoms was achieved in 35.8% of the NERD group and 55.4% of the erosive GERD group (mild RO: 51.1% and severe RO: 77.8%). Rabeprazole was significantly more effective in erosive GERD than in NERD patients. Among the NERD subgroups (Grades N and M), no difference in symptom improvement was observed.Conclusions Four-week, rabeprazole 10 mg/day acid suppression therapy was effective in resolving symptoms in Japanese GERD patients. This therapy was more effective in erosive GERD than in NERD patients, and in those with severe RO than in those with mild RO.