Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study
Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study
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DOI：
10.1093/eurheartj/ehz520
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发表时间：
2020-01-14
影响因子：
39.3
通讯作者：
Arbustini, Eloisa
中科院分区：
文献类型：
--
作者：
Prati, Francesco;Romagnoli, Enrico;Arbustini, Eloisa
目的 CLIMA 研究涉及左前降支冠状动脉斑块形态与 12 个月临床结果之间的关系，旨在探讨 OCT 检测到的同一冠状动脉病变中多个高风险斑块特征的预测价值 [最小管腔面积 (MLA)、纤维帽厚度 (FCT)、脂质弧圆周延伸和光学相干断层扫描 (OCT) 定义的巨噬细胞的存在]。心源性死亡和靶节段心肌梗死的复合终点是主要临床终点。 方法和结果 从 2013 年 1 月到 2016 年 12 月，在 11 个独立中心（clinicattriaLgov 标识符 NCT02883088）前瞻性入组了 1003 名患者，这些患者在临床指示的冠状动脉造影背景下对未经治疗的近端左前降支进行 OCT 评估。 1 年时，在 37 名患者 (3.7%) 中观察到主要临床终点。在总共 1776 个脂质斑块中，存在 MLA
Aims The CLIMA study, on the relationship between coronary plaque morphology of the left anterior descending artery and twelve months clinical outcome, was designed to explore the predictive value of multiple high-risk plaque features in the same coronary lesion [minimum lumen area (MLA), fibrous cap thickness (FCT), lipid arc circumferential extension, and presence of optical coherence tomography (OCT)-defined macrophages] as detected by OCT. Composite of cardiac death and target segment myocardial infarction was the primary clinical endpoint.Methods and results From January 2013 to December 2016, 1003 patients undergoing OCT evaluation of the untreated proximal left am :sults anterior descending coronary artery in the context of clinically indicated coronary angiogram were prospectively enrolled at 11 independent centres (clinicattriaLgov identifier NCT02883088). At 1-year, the primary clinical endpoint was observed in 37 patients (3.7%). In a total of 1776 lipid plaques, presence of MLA