Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia
Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia
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DOI：
10.1126/science.1104784
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发表时间：
2005-03-18
期刊：
影响因子：
56.9
通讯作者：
Dahmann, C
中科院分区：
文献类型：
--
作者：
Shen, J;Dahmann, C
Decapentaplegic（Dpp）是一种信号分子，控制发育中的果蝇翅膀的生长和图案化。缺乏Dpp信号转导的突变细胞已被证明激活c-Jun氨基末端激酶（JNK）依赖性细胞凋亡，并从翼盘上皮丢失。这些观察结果导致了Dpp通过防止细胞凋亡促进细胞存活的假设。在这里，我们表明，在JNK依赖性细胞凋亡的情况下，突变细胞tacking Dpp信号转导可以生存，但是，他们仍然失去了从翼盘上皮。这种损失与广泛的细胞骨架的变化，然后基底上皮挤出。我们认为Dpp通过影响细胞骨架组织来促进椎间盘上皮细胞的存活。
Decapentaplegic (Dpp) is a signaling molecule that controls growth and patterning of the developing Drosophila wing. Mutant cells lacking Dpp signal transduction have been shown to activate c-Jun amino-terminal kinase (JNK)-dependent apoptosis and to be lost from the wing disc epithelium. These observations have led to the hypothesis that Dpp promotes cell survival by preventing apoptosis. Here, we show that in the absence of JNK-dependent apoptosis, mutant cells tacking Dpp signal transduction can survive; however, they are still lost from the wing disc epithelium. This loss correlates with extensive cytoskeletal changes followed by basal epithelial extrusion. We propose that Dpp promotes cell survival within disc epithelia by affecting cytoskeletal organization.