Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats.
Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats.
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甘氨酸延长胃泌素增强大鼠胃泌素刺激的胃酸分泌。
DOI：
10.1152/ajpgi.1996.270.1.g220
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Thompson,JC
中科院分区：
文献类型：
--
作者：
Higashide,S;Gomez,G;GreeleyJr,GH;TownsendJr,CM;Thompson,JC
The purpose of this study was to examine whether an intermediate form of amidated gastrin, glycine-extended gastrin (Gly-G), can stimulate gastric acid secretion in conscious rats prepared with gastric fistulas. Intravenous administration of Gly-G (20 nmol.kg-1.h-1) alone for 2 h did not stimulate gastric acid secretion; however, administration of Gly-G (20 nmol.kg-1.h-1) in combination with a bolus administration of gastrin (9.5 nmol/kg) potentiated acid secretion significantly. Gastric acid secretion in response to gastrin alone and gastrin plus Gly-G (2 nmol.kg-1.h-1) was 109.1 +/- 21.6 and 170.1 +/- 27.7 mueq.kg-1.h-1, respectively (P < 0.05). Gastric acid secretion in response to gastrin alone and gastrin plus Gly-G (20 nmol.kg-1.h-1) was 84.8 +/- 17.5 and 164.1 +/- 29.3 mueq.kg-1.h-1, respectively (P < 0.05). Intravenous administration of Gly-G (20 nmol.kg-1.h-1) failed to increase histamine (1 mg/kg)-stimulated acid output. These results demonstrate that Gly-G can selectively potentiate the stimulatory effect of gastrin on acid secretion in rats and that the unprocessed form of gastrin, Gly-G, can exert a biological effect in the stomach.
