Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
复制标题
DOI：
10.3945/ajcn.110.003970
复制
发表时间：
2010-12-01
影响因子：
7.1
通讯作者：
Hotamisligil, Gokhan S.
中科院分区：
文献类型：
--
作者：
Mozaffarian, Dariush;Cao, Haiming;Hotamisligil, Gokhan S.
背景动物实验表明，来自脂肪细胞从头合成的循环棕榈油酸(cis 16 1n-7)可能直接调节胰岛素抵抗和代谢紊乱目的我们调查了自由生活的人类循环棕榈油酸的独立决定因素，以及棕榈油酸是否与较低的代谢风险和糖尿病的发病率有关。设计采用前瞻性队列设计，对参加心血管健康研究的3630名美国男性和女性进行前瞻性队列研究，采用标准化方法测量血脂、炎症标志物、葡萄糖和胰岛素浓度，采用多元调整线性回归分析血浆磷脂棕榈酸酯的独立决定因素以及棕榈油酸与代谢危险因素的关系。结果平均(+/-SD)棕榈油酸酯占总脂肪酸的0 49+/-0 2 0%(范围0 11~2 5 5%)与生活方式、碳水化合物摄入量、蛋白质摄入量和饮酒有关。在调整这些因素和其他潜在混杂因素的多变量分析中，棕榈油酸酯浓度高与低密度脂蛋白胆固醇水平相关(P<；更高的高密度脂蛋白胆固醇(P<；00001)，低总高密度脂蛋白胆固醇比率(P=004)和低纤维蛋白原(P<；00001)，而棕榈油酸酯也与更高的甘油三酯(P<；00001)和(仅在男性)有更大的胰岛素抵抗(P<；0001)有关。结论肥胖(能量失衡)、碳水化合物摄入和饮酒--即使在典型范围内--与较高的循环棕榈酸酯浓度有关，循环棕榈酸酯与多种代谢危险因素密切相关，但在混合方向上，可能与潜水者的生活方式决定因素或脂肪酸合成的内源性来源(肝脏脂肪组织)有关，临床杂志，2010 92 1350-8
Background Animal experiments suggest that circulating palmitoleic acid (cis 16 1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance and metabolic dysregulationObjective We investigated the independent determinants of circulating palmitoleate in free living humans and whether palmitoleate is related to lower metabolic risk and the incidence of diabetesDesign In a prospective cohort of 3630 US men and women in the Cardiovascular Health Study plasma phospholipid fatty acids anthropometric variables blood lipids inflammatory markers and glucose and insulin concentrations were measured between 1992 and 2006 by using standardized methods Independent determinants of plasma phospholipid palmitoleate and relations of palmitoleate with metabolic risk factors were investigated by using multivariable adjusted linear regression Relations with incident diabetes (296 incident cases) were investigated by using Cox proportional hazardsResults The mean (+/- SD) palmitoleate value was 0 49 +/- 0 20% (range 0 11-2 55%) of total fatty acids Greater body mass index carbohydrate intake protein intake and alcohol use were each in dependent lifestyle correlates of higher palmitoleate concentrations In multivariable analyses that adjusted for these factors and other potential confounders higher palmitoleate concentrations were in dependently associated with lower LDL cholesterol (P < 0 001) higher HDL cholesterol (P < 0 001) lower total HDL cholesterol ratio (P = 0 04) and lower fibrinogen (P < 0 001) However palmitoleate was also associated with higher triglycerides (P < 0 001) and (in men only) with greater insulin resistance (P < 0 001) Palmitoleate was not significantly associated with incident diabetesConclusions Adiposity (energy imbalance) carbohydrate consumption and alcohol use-even within typical ranges-are associated with higher circulating palmitoleate concentrations Circulating palmitoleate is robustly associated with multiple metabolic risk factors but in mixed directions perhaps related to diver gent lifestyle determinants or endogenous sources (liver adipose tissue) of fatty acid synthesis An, J Clin Nutr 2010 92 1350-8