Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence
Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence
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DOI：
10.1016/j.euroneuro.2012.08.016
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发表时间：
2013-09-01
影响因子：
5.6
通讯作者：
Casas, Miguel
中科院分区：
文献类型：
--
作者：
Corominas-Roso, Margarida;Roncero, Carlos;Casas, Miguel
临床前研究表明，脑源性神经营养因子（BDNF）参与了戒断后持久寻求可卡因的神经可塑性变化。然而，对早期戒断可卡因依赖患者血清BDNF水平的时间变化或BDNF在渴望和戒断中的作用知之甚少。23名可卡因依赖者（年龄33.65 +/- 6.85岁）在一家住院机构完成了为期两周的戒毒计划。在基线和方案结束时为每位患者收集两份血清样本。同时采集46例健康对照（年龄35.52±9.37岁）的血清样本。记录所有患者的人口统计、消费和临床数据。血清BDNF水平显著降低(p
Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65 +/- 6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52 +/- 9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p