Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
复制标题
急性髓性白血病患者对柔红霉素获得了耐药性。
作者：
B. J. Smith;D. Kundu;St Bartholomew 's Hospital;E. London
AML患者体内和体外对柔红霉素耐药性的测量表明，两者之间没有简单的相关性。在一个患者谁成为临床耐药，其细胞在体外表现出平行增加的阻力，我们发现收购的多重耐药。体外柔红霉素耐药性的增加可以在一定程度上通过柔红霉素与DNA的结合来克服。
Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA.