ERBB2 kinase domain mutation in a gastric cancer metastasis
ERBB2 kinase domain mutation in a gastric cancer metastasis
复制标题
DOI：
10.1111/j.1600-0463.2005.apm_284.x
复制
发表时间：
2005-10-01
期刊：
影响因子：
2.8
通讯作者：
Lee, SH
中科院分区：
文献类型：
--
作者：
Lee, JW;Soung, YH;Lee, SH
ERBB 2是表皮生长因子受体（EGFR）家族的成员。最近的研究表明，ERBB 2基因的激酶结构域在人类癌症（包括胃癌）中发生突变。尽管癌症转移在癌症发病机制中的重要性，但缺乏关于癌症转移中ERBB 2激酶结构域突变的数据。为了探讨ERBB 2突变与胃癌转移的关系，我们对58例胃癌淋巴结转移患者ERBB 2激酶区进行了突变检测。我们发现了一个ERBB 2突变，这是在淋巴结转移中检测到的，而不是在同一患者的原发肿瘤。ERBB 2突变为错义突变，在第21外显子（V832 I）上替换了一个氨基酸。我们同时分析了具有ERBB 2突变的样本中EGFR、K-RAS、PIK 3CA和BRAF基因的体细胞突变，发现该转移性癌不携带任何突变。我们的数据表明，ERBB 2激酶结构域突变偶尔发生在转移性胃癌，并可能在某些胃癌的转移过程中发挥作用。
ERBB2 is a member of the epidermal growth factor receptor (EGFR) family. Recent studies revealed that the kinase domain of the ERBB2 gene was mutated in human cancers, including gastric cancer. Despite the importance of cancer metastasis in the pathogenesis of cancers, data on the ERBB2 kinase domain mutation in cancer metastasis are lacking. In this study, to explore the possibility that ERBB2 mutation is involved in the metastasis mechanism, we analyzed the kinase domain of ERBB2 for the detection of somatic mutations in 58 gastric adenocarcinomas with lymph node metastasis. We found one ERBB2 mutation, which was detected in the lymph node metastasis, but not in the primary tumor of the same patient. The ERBB2 mutation was a missense mutation which substituted an amino acid in exon 21 (V832I). We simultaneously analyzed the somatic mutations of EGFR, K-RAS, PIK3CA and BRAF genes in the sample with the ERBB2 mutation, and found that this metastatic carcinoma did not harbor any of the mutations. Our data suggest that ERBB2 kinase domain mutation occasionally occurs in metastatic gastric carcinoma and might play a role in the metastatic process of some gastric carcinomas.