Cytoskeleton-membrane interactions
Cytoskeleton-membrane interactions
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DOI：
10.1016/s0955-0674(96)80049-4
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发表时间：
1996-02-01
影响因子：
7.5
通讯作者：
Burke, B
中科院分区：
文献类型：
--
作者：
Cowin, P;Burke, B
细胞骨架和细胞膜之间的关联，无论是在细胞内还是在细胞接触点，在决定细胞形状和组织完整性方面发挥着核心作用。在过去的几年中，已经清楚的是，许多这些细胞骨架-膜相互作用远远超出了简单的机械连接。例如，作为连接分子的蛋白质在粘附连接处和质膜中的桥粒在信号转导途径中具有新认识的功能。这些功能对发育过程中的细胞行为有着深远的影响。此外，在细胞核内，中间丝蛋白家族的核纤层蛋白分支似乎通过与整合膜蛋白的广泛相互作用在限定内核膜的蛋白质组成方面具有关键作用。这些完整的膜蛋白的身份现在才开始曝光。
Associations between the cytoskeleton and cellular membranes, both within the cell and at points of cell contact, play a central role in determining cell shape and tissue integrity, During the past few years, it has become clear that many of these cytoskeleton-membrane interactions go far beyond simple mechanical linkages. For example, proteins that act as linker molecules at the adherens junctions and desmosomes in the plasma membrane have newly recognized functions in signal transduction pathways. These functions have profound effects on cell behaviour during development. In addition, within the nucleus, the lamin branch of the intermediate filament protein family appears to have a key role in defining the protein composition of the inner nuclear membrane by means of extensive interactions with integral membrane proteins. The identities of these integral membrane proteins are only now coming to light.