Meiotic Spindle Assembly and Chromosome Segregation in Oocytes
Meiotic Spindle Assembly and Chromosome Segregation in Oocytes
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DOI：
10.1002/9780470687970.ch10
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发表时间：
2010-04
期刊：
影响因子：
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通讯作者：
J. Dumont;S. Brunet
中科院分区：
文献类型：
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作者：
J. Dumont;S. Brunet
卵子发生——雌性生殖细胞发育成成熟卵子或卵子的过程——是一个复杂的过程，涉及发育和细胞生物学的许多重要元素：细胞间相互作用、复杂的信号级联、专门的细胞周期和细胞骨架组织。来自不同物种（包括蛤、海星、爪蟾和小鼠）的卵母细胞是研究细胞分裂生物化学的优秀模型系统，对基础和临床研究具有重要意义。本书按时间顺序描述了卵子发生的整个过程，其中包括国际领先研究人员的贡献以及涵盖卵子生物学的医学和伦理考虑的章节。主题包括性别决定和性腺发育、减数分裂染色体配对和同源重组的控制、减数分裂的控制和卵母细胞重塑为全能合子以及医学辅助生殖。
Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research. This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction.