From transcriptional complexity to cellular phenotypes: Lessons from yeast

From transcriptional complexity to cellular phenotypes: Lessons from yeast
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DOI：
10.1002/yea.3277
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发表时间：
2017-09
期刊：
Yeast
影响因子：
2.6
通讯作者：
V. Pelechano
V. Pelechano
中科院分区：
生物学4区
文献类型：
--
作者：
V. Pelechano

文献摘要

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在许多真核生物中已经报道了普遍转录，揭示了涉及数千个编码和非编码RNA的高度交错的转录组组织。然而，迄今为止，转录组复杂性的生物学影响仍然知之甚少。在这里，我将回顾转录组的微妙变化如何通过微调其编码潜力和调控导致不同的细胞表型。我将讨论可用于将分子变异与不同的生物学结果联系起来的策略。最后，我将探讨转录复杂性对我们理解细胞间表型变异背景下基因表达的影响。版权所有© 2017约翰威利父子有限公司
Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non‐coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine‐tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell‐to‐cell phenotypic variability. Copyright © 2017 John Wiley & Sons, Ltd.