Citrus Fruit Intake and Pancreatic Cancer Risk A Quantitative Systematic Review
Citrus Fruit Intake and Pancreatic Cancer Risk A Quantitative Systematic Review
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DOI：
10.1097/mpa.0b013e318188c497
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发表时间：
2009-03-01
期刊：
影响因子：
2.9
通讯作者：
Guyatt, Gordon
中科院分区：
文献类型：
--
作者：
Bae, Jong-Myon;Lee, Eun Ja;Guyatt, Gordon
目的：本系统综述的目的是调查饮食中柑橘类水果的摄入量与胰腺癌风险之间的关系。方法：作者检索电子数据库和截至2007年12月的饮食与胰腺癌研究的参考文献列表。所有获得柑橘类水果饮食摄入量的个人数据并提出柑橘类水果摄入量与胰腺癌风险之间关系的风险评估的流行病学研究都被确定并纳入其中。采用基于一般方差的方法，从每篇文章中提取柑橘类水果最高和最低摄入量的研究特定优势比(OR)/相对风险和相关可信区间(CI)/SE。结果：9篇文章包括4篇病例对照研究和5项队列研究，证明符合条件。总体总结OR使用随机效应模型显示胰腺癌的风险与柑橘类水果的摄入量呈负相关(摘要OR，0.83；95%CI，0.70-0.98)，且在研究中具有很大的异质性(I-2=49.9%)。结论：观察性研究的汇集结果显示，柑橘类水果的摄入量与胰腺癌风险呈负相关，尽管不同研究的结果有很大差异，而且明显的效果仅限于较弱的研究设计(病例对照研究)。
Objectives: The purpose of this systematic review was to investigate the association between dietary intake of citrus fruits and pancreatic cancer risk.Methods: Authors searched electronic databases and the reference lists of publications of studies addressing diet and pancreatic cancer up to December 2007. All of the epidemiological studies that obtained individual data on dietary intake of citrus fruits and presented risk estimates of the association between intake of citrus fruits and risk of pancreatic cancer were identified and included. Using general variance-based methods, study-specific odds ratios (ORs)/relative risk and associated confidence interval (CI)/SE for highest versus lowest intake of citrus fruits level were extracted from each article.Results: Nine articles including 4 case-control studies and 5 cohort studies proved eligible. Overall summary OR using random effect model suggested an inverse association in risk of pancreatic caner with intake of citrus fruits (summary OR, 0.83; 95% CI, 0.70-0.98) with large heterogeneity across studies (I-2 = 49.9%).Conclusions: Pooled results from observational studies showed an inverse association between intake of citrus fruits and the risk of pancreatic cancer, although results vary substantially across studies, and the apparent effect is restricted to the weaker study design (case-control studies).