Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and-2 suggests an important role of astrocytes in cerebellar vascularization
Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and-2 suggests an important role of astrocytes in cerebellar vascularization
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DOI：
10.1016/s0925-4773(01)00471-3
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发表时间：
2001-10-01
影响因子：
2.6
通讯作者：
Plate, KH
中科院分区：
文献类型：
--
作者：
Acker, T;Beck, H;Plate, KH
中枢神经系统的血管化是通过血管生成发芽发生的，在这个过程中，不同的因子，如血管内皮生长因子（VEGF）和血管生成素(Ang)-1/2必须协同作用。我们研究了这些因素如何参与小脑的毛细血管化，这是一个在出生后发育过程中经历显著重组过程的区域。VEGF和Ang-1 mRNA主要在星形胶质细胞中表达，而Ang-2 mRNA在侵袭的内皮细胞索尖端被特异性诱导。与大脑皮层类似，小脑的血管形成以一种由内向外的模式发生，密切跟随每一小脑层的产生和分化。VEGF和Ang-1/2的表达模式以类似的由内向外的方式改变，支持它们在血管生长和成熟中的功能。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
The vascularization of the central nervous system occurs by angiogenic sprouting, a process in which different factors like vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1/2 must act in a coordinated fashion. We investigated how these factors participate in capillarization of the cerebellum, an area experiencing marked reorganization processes during its postnatal development. VEGF and Ang-1 mRNA were predominantly expressed by astrocytes, while Ang-2 mRNA was specifically induced at the tip of invading endothelial cell cords. Similar to the cerebral cortex, vascularization of the cerebellum occurred in an inside-out pattern, following closely the generation and differentiation of each cerebellar layer. VEGF and Ang-1/2 expression patterns shifted in a similar inside-out fashion, supporting their proposed function in vessel growth and maturation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.