Computational model for cell morphodynamics.
Computational model for cell morphodynamics.
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DOI：
10.1103/physrevlett.105.108104
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发表时间：
2010-09-03
影响因子：
8.6
通讯作者：
Levine H
中科院分区：
文献类型：
--
作者：
Shao D;Rappel WJ;Levine H
We develop a computational model, based on the phase field method, for cell morphodynamics and apply it to fish keratocytes. Our model incorporates the membrane bending force and the surface tension and enforces a constant area. Furthermore, it implements a cross linked actin filament field and an actin bundle field that are responsible for the protrusion and retraction forces, respectively. We show that our model predicts steady state cell shapes with a wide range of aspect ratios, depending on system parameters. Furthermore, we find that the dependence of the cell speed on this aspect ratio matches experimentally observed data.
