Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis
Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis
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DOI：
10.1902/jop.2000.71.11.1756
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发表时间：
2000-11-01
影响因子：
4.3
通讯作者：
Bulut, S
中科院分区：
文献类型：
--
作者：
Bozkurt, FY;Berker, E;Bulut, S
背景资料：为探讨类风湿关节炎（RA）和成人牙周炎（AP）患者龈沟液（GCF）中白细胞介素-6（IL-6）水平与牙周临床表现的关系，将45例RA和AP患者分为3组，其中RA和AP组15例，AP组15例，牙周健康对照组15例。记录每位患者的菌斑指数（PI）、牙龈指数（GI）、龈沟出血指数（SBI）、探诊深度（PD）和附着水平（AL）值。结果：RA组与AP组除PI外，其他临床指标均无显著性差异（P> 0.05）。虽然RA组的平均GCF IL-6水平最高，但各组间无显著差异。RA组GCF中IL-6水平与GI评分之间仅呈强负相关。在RA患者中，尽管由于自身免疫和PI水平高于AP患者而增加了局部组织破坏潜力，但我们的研究结果表明，包括皮质类固醇和非甾体抗炎药在内的药物可能会减少牙龈炎症，但RA患者牙龈组织中IL-6的合成和降解可能存在差异。据我们所知，这项研究是第一个报告确定GCF IL-6水平在RA患者。
Background: The aim of this study was to determine and compare interleukin-6 (IL-6) levels in gingival crevicular fluid (GCF) and clinical periodontal findings in patients with rheumatoid arthritis (RA) and adult periodontitis (AP).Methods: A total of 45 patients divided into 3 groups (15 patients with RA and AP, 15 patients with AP, and 15 periodontally healthy subjects) were included in this study. Plaque index (PI), gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), and attachment level (AL) values for each patient were recorded. Enzyme-linked immunosorbent assay for quantitative detection of IL-6 in each GCF sample was employed.Results: No significant difference could be detected between the RA and AP groups in the mean clinical parameter data except PI. Although the mean GCF IL-6 level in the RA group was the highest, no significant difference could be found among the groups. There was only a strong negative correlation between GCF IL-6 levels and GI scores in the RA group.Conclusions: In the patients with RA, despite increased local tissue destruction potential due to autoimmunity and higher PI levels than in the AP patients, our findings suggest that medication including corticosteroid and non-steroidal anti-inflammatory drugs may decrease gingival inflammation, but the synthesis and degradation of IL-6 in gingival tissue of RA patients may be different. To our knowledge, this study is the first report determining GCF IL-6 levels in RA patients.