Local Allergic Rhinitis
Local Allergic Rhinitis
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DOI：
10.1016/j.iac.2015.12.008
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发表时间：
2016-05-01
影响因子：
2.6
通讯作者：
Rondon, Carmen
中科院分区：
文献类型：
--
作者：
Campo, Paloma;Salas, Maria;Rondon, Carmen
本文着重介绍局部变应性鼻炎，变应性鼻炎的一种新表型，常被误诊为非变应性鼻炎。在过去的十年里，它已经引起了人们的注意，可以影响所有国家、民族和年龄的患者，损害他们的生活质量，并经常与结膜炎和哮喘有关。诊断依据是临床病史、鼻部过敏原激发试验阳性反应和/或鼻部sIgE检测。嗜碱性粒细胞活化试验阳性可能支持诊断。最近的研究表明，变应原免疫疗法是一种有效的免疫调节疗法，强调了早期诊断的重要性。
This review focuses on local allergic rhinitis, a new phenotype of allergic rhinitis, commonly misdiagnosed as nonallergic rhinitis. It has gained attention over last decade and can affect patients from all countries, ethnic groups and ages, impairing their quality of life, and is frequently associated with conjunctivitis and asthma. Diagnosis is based on clinical history, the demonstration of a positive response to nasal allergen provocation test and/or the detection of nasal sIgE. A positive basophil activation test may support the diagnosis. Recent studies have demonstrated that allergen immunotherapy is an effective immune-modifying treatment, high-lighting the importance of early diagnosis.