Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis
Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis
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DOI：
10.1007/s11255-021-03032-0
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发表时间：
2021-10-21
影响因子：
2
通讯作者：
Papasotiriou, Marios
中科院分区：
文献类型：
--
作者：
Plytzanopoulou, Petrini;Politis, Panagiotis;Papasotiriou, Marios
肌肉减少症是一种临床疾病，包括骨骼肌（SM）质量和SM强度下降，是血液透析（HD）患者身体残疾、生活质量受损、晚期发病率和死亡率的危险因素。在临床实践中，用负担得起的和实用的方法评估SM质量和因此的肌肉减少症的现有困难是公认的。本研究的目的是检查肌酸酐指数（CrI），SM质量的替代品，作为肌肉减少症的潜在预测指标。方法在这项横断面研究中，我们纳入了130例HD患者，平均年龄为66.17 ± 12.47岁。SM质量和SM强度分别用CrI和握力进行评价。还进行了人体测量、肥胖、营养和生化评估。偏相关和多元回归分析，以探讨之间的关联CrI和SM强度。结果相关分析显示，上臂围、小腿围、老年营养指数、白蛋白/总蛋白比值与SM强度呈正相关。多变量模型表明，CrI（β = 2.05，p < 0.001）和透析持续时间（β =-0.53，p = 0.001）与SM强度独立相关。CrI和SM强度之间的显著正相关性即使在调整潜在混杂因素后仍不受影响。结论：Creeps指数与SM强度显著相关，突出了其作为HD患者中临床设置肌肉减少症的新的实用预测标记物的价值。
Purpose Sarcopenia is a clinical condition that comprises declined skeletal muscle (SM) mass and SM strength, and is a risk factor for physical disability, impaired quality of life, and advanced morbidity and mortality in patients on hemodialysis (HD). The existing difficulty in evaluating SM mass and consequently of sarcopenia, with affordable and practical methods in clinical practice, is well established. The purpose of this study is to examine the creatinine index (CrI), a surrogate of SM mass, as a potential predictive marker of sarcopenia. Methods In this cross-sectional study, we included 130 patients on HD with a mean age of 66.17 +/- 12.47 years. SM mass and SM strength were evaluated with CrI and hand grip strength, respectively. Anthropometric, adiposity, nutritional, and biochemical assessments were also performed. Partial correlation and multivariate regression analyses were applied to investigate the association between CrI and SM strength. Results Correlation analysis showed that mid-arm circumference, calf circumference, Geriatric nutritional index, and albumin-to-total protein ratio were positively associated with SM strength. Multivariate model indicated that CrI (beta = 2.05, p < 0.001) and dialysis duration (beta =- 0.53, p = 0.001) were independently related to SM strength. The significant positive correlation between CrI and SM strength remained unaffected even after adjusting for potential confounders. Conclusions Creatinine Index was significantly associated with SM strength highlighting its value as a new emerging practical in clinical setting sarcopenia predictive marker in HD patients.