Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.
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DOI：
10.1186/1471-230x-8-56
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发表时间：
2008-11-26
影响因子：
2.4
通讯作者：
Takeyama H
中科院分区：
文献类型：
--
作者：
Sawai H;Yasuda A;Ochi N;Ma J;Matsuo Y;Wakasugi T;Takahashi H;Funahashi H;Sato M;Takeyama H
肿瘤抑制蛋白磷酸酶和张力蛋白同源物（PTEN）是细胞存活信号传导的重要负调节因子。为了评价结直肠癌肝转移患者和无肝转移患者中PTEN表达与临床病理特征的相关性，我们研究了原发性结直肠癌和结直肠癌肝转移患者中PTEN的表达。对69例原发性结直肠癌及相应肝转移灶标本进行免疫组化分析，并探讨其与临床病理因素的关系。70例无肝转移的原发性结直肠癌标本作为对照。PTEN在44例（62.9%）无肝转移的结直肠癌标本中呈强表达。相反，PTEN在52例（75.4%）肝转移患者的原发性结直肠癌标本中弱表达，而在肝转移中不表达。结直肠癌组织中PTEN的弱表达与TNM分期（p < 0.01）和淋巴结转移（p < 0.05）显著相关。在无肝转移患者的原发性结直肠癌标本中，PTEN表达显著增强。此外，在伴有肝转移的结直肠癌患者中，与PTEN阴性表达的患者相比，PTEN阳性表达的患者的5年生存率显著更高（p = 0.012）。我们的研究结果表明，PTEN表达的损失与结直肠癌的侵袭能力和诊断评估的PTEN表达可能提供有价值的预后信息，以帮助结直肠癌患者的治疗策略。
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases. Sixty-nine pairs of primary colorectal cancer and corresponding liver metastasis specimens were analyzed immunohistochemically, and the correlation between immunohistochemical findings and clinicopathological factors was investigated. Seventy primary colorectal cancer specimens from patients without liver metastases were used as controls. PTEN was strongly expressed in 44 (62.9%) colorectal cancer specimens from patients without liver metastases. In contrast, PTEN was weakly expressed in 52 (75.4%) primary colorectal cancer specimens from patients with liver metastases, and was absent in liver metastases. Weak PTEN expression in colorectal cancer tissues was significantly associated with advanced TNM stage (p < 0.01) and lymph node metastasis (p < 0.05). PTEN expression was significantly stronger in primary colorectal cancer specimens from patients without liver metastases. Furthermore, among colorectal cancer patients with liver metastases, the 5-year survival rate was significantly higher in patients with positive PTEN expression compared to those with negative PTEN expression (p = 0.012). Our results suggest that loss of PTEN expression is involved with colorectal cancer aggressive capacity and that diagnostic evaluation of PTEN expression may provide valuable prognostic information to aid treatment strategies for colorectal cancer patients.