Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention.
Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention.
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DOI：
10.3390/cancers8060058
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发表时间：
2016-06-20
期刊：
影响因子：
5.2
通讯作者：
Cebolla-Cornejo J
中科院分区：
文献类型：
--
作者：
Martí R;Roselló S;Cebolla-Cornejo J
富含蔬菜的饮食与许多与衰老和现代生活方式有关的疾病的风险降低有关。在过去的几十年里，许多研究已经指出，摄入番茄中存在的生物活性化合物与降低患不同类型癌症的风险之间存在直接关系。这些生物活性成分包括植物化学物质如类胡萝卜素和多酚。这些化学保护分子的直接摄入似乎显示出更高的效率，当它们被摄入其天然生物基质比当它们被单独摄入或在膳食补充剂。因此，提高食品中这些生物活性化合物含量的趋势越来越明显。控制生长环境和加工条件可以确保生物活性化合物的最大潜在积累或适度损失，但最好的结果是通过植物育种开发新品种。通过常规育种或基因工程对代谢途径的单个步骤的修饰或其调节在作物如番茄中提供了优异的结果。在这篇综述中，我们分析了番茄作为具有癌症预防特性的生物活性成分来源的潜力，以及现代育种计划作为增加饮食中这些化合物水平的策略的结果。
A diet rich in vegetables has been associated with a reduced risk of many diseases related to aging and modern lifestyle. Over the past several decades, many researches have pointed out the direct relation between the intake of bioactive compounds present in tomato and a reduced risk of suffering different types of cancer. These bioactive constituents comprise phytochemicals such as carotenoids and polyphenols. The direct intake of these chemoprotective molecules seems to show higher efficiencies when they are ingested in its natural biological matrix than when they are ingested isolated or in dietary supplements. Consequently, there is a growing trend for improvement of the contents of these bioactive compounds in foods. The control of growing environment and processing conditions can ensure the maximum potential accumulation or moderate the loss of bioactive compounds, but the best results are obtained developing new varieties via plant breeding. The modification of single steps of metabolic pathways or their regulation via conventional breeding or genetic engineering has offered excellent results in crops such as tomato. In this review, we analyse the potential of tomato as source of the bioactive constituents with cancer-preventive properties and the result of modern breeding programs as a strategy to increase the levels of these compounds in the diet.