Comparative patterns of cognitive performance amongst opioid maintenance patients, abstinent opioid users and non-opioid users
Comparative patterns of cognitive performance amongst opioid maintenance patients, abstinent opioid users and non-opioid users
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DOI：
10.1016/j.drugalcdep.2012.05.032
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发表时间：
2012-12-01
影响因子：
4.2
通讯作者：
Torok, Michelle
中科院分区：
文献类型：
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作者：
Darke, Shane;McDonald, Skye;Torok, Michelle
背景资料：比较海洛因依赖者（MAIN）、戒断者（ABST）和健康非海洛因使用者（CON）的认知能力。125例MAIN病例对照研究（94名受试者维持美沙酮，31名维持丁丙诺啡），50名ABST和50名CON。神经心理学测试测量执行功能，工作记忆，信息处理速度，语言学习和非语言学习管理。结果：有没有对美沙酮或丁丙诺啡对任何管理测试的认知配置文件之间的差异。在控制混杂因素后，在13项测试中，MAIN组的表现比对照组差，在5项测试中比ABST组差。MAIN组在Haylings句子完成，矩阵推理，数字符号，逻辑记忆（即时和延迟回忆）和复杂图形测试（即时回忆）中表现较差。有ABST和CON组之间没有任何差异的任何管理tests.Conclusions：POSTANY认知性能，在一系列的测试和域，被认为是维持患者之间，无论他们的维持药物。这是一个可能受益于管理因大脑功能障碍而产生认知和行为困难的个人的方法的群体。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Background: To compare the cognitive performances of maintenance patients (MAIN), abstinent ex-users (ABST) and healthy non-heroin using controls (CON).Methods: Case control study of 125 MAIN (94 subjects maintained on methadone, 31 on buprenorphine), 50 ABST and 50 CON. Neuropsychological tests measuring executive function, working memory, information processing speed, verbal learning and non-verbal learning were administered.Results: There were no differences between the cognitive profiles of those maintained on methadone or buprenorphine on any administered test. After controlling for confounders, the MAIN group had poorer performance than controls in six of the 13 administered tests, and were poorer than the ABST group in five. The MAIN group exhibited poorer performance in the Haylings Sentence Completion, Matrix Reasoning, Digit Symbol, Logical Memory (immediate and delayed recall), and the Complex Figure Test (immediate recall). There were no differences between the ABST and CON groups on any of the administered tests.Conclusions: Poorer cognitive performance, across a range of test and domains, was seen amongst maintenance patients, regardless of their maintenance drug. This is a group that is likely might benefit from approaches for managing individuals with cognitive and behavioural difficulties arising from brain dysfunction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.