Association of IGF1 gene polymorphism with Parkinson's disease in a Han Chinese population.
Association of IGF1 gene polymorphism with Parkinson's disease in a Han Chinese population.
复制标题
中国汉族人群 IGF1 基因多态性与帕金森病的关联
DOI：
10.1002/jgm.2949
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发表时间：
2017
影响因子：
3.5
通讯作者：
Xu Pingyi
中科院分区：
文献类型：
--
作者：
Xiao Yousheng;Cen Luan;Mo Mingshu;Chen Xiang;Huang Shuxuan;Wei Lei;Li Shaomin;Yang Xinling;Qu Shaogang;Pei Zhong;Xu Pingyi
背景越来越多的证据表明胰岛素样生长因子1（IGF 1）在帕金森病（PD）的发病机制中起重要作用。然而，目前尚不清楚是否IGF 1多态性有助于PD risk.MethodsWe进行了一项病例对照研究，在汉族人群，其中包括512散发PD病例和535匹配的控制。使用Sequenom MassARRAY iPLEX平台对所有参与者进行rs 972936基因分型。血清IGF 1水平的61初治，药物初治PD患者和55年龄和性别匹配的控制也测量使用酶联免疫吸附试验。Results 972936-CC基因型频率与PD风险增加显着相关（p= 0.009），特别是在男性（p= 0.024）和晚发型患者（p= 0.013）。与对照组相比，初治PD患者的血清IGF 1水平显著升高（p= 0.036），尽管它们与PD患者的运动功能障碍无关（p= 0.220）。此外，高血清IGF 1水平可能是中国汉族人群PD的潜在诊断生物标志物，尽管它们与更严重的运动功能障碍无关。
BackgroundAccumulating evidence suggests that insulin‐like growth factor 1 (IGF1) plays an important role in Parkinson's disease (PD) pathogenesis. However, it is not clear whetherIGF1polymorphism contributes to PD risk.MethodsWe performed a case–control study in a Han Chinese population that included 512 sporadic PD cases and 535 matched controls. All participants were genotyped for rs972936 using the Sequenom MassARRAY iPLEX platform. Serum IGF1 levels of 61de novo, drug‐naïve PD patients and 55 age‐ and sex‐matched controls were also measured using an enzyme‐linked immunosorbent assay.ResultsGenotype frequency of rs972936‐CC was significantly associated with an increased PD risk (p= 0.009), especially in males (p= 0.024) and late‐onset patients (p= 0.013). Serum IGF1 levels were significantly increased inde novo, drug‐naïve PD patients compared to controls (p= 0.036), although they were not correlated with motor dysfunction in PD patients (p= 0.220).ConclusionsThe present study shows that rs972936 polymorphism may increase susceptibility to PD, especially in males and late‐onset patients. Furthermore, high serum IGF1 levels may be a potential diagnostic biomarker for PD in the Han Chinese population, although they do not correlate with a more severe motor dysfunction.