Results of blood inflammatory markers are associated more strongly with toe-brachial index than with ankle-brachial index in patients with type 2 diabetes
Results of blood inflammatory markers are associated more strongly with toe-brachial index than with ankle-brachial index in patients with type 2 diabetes
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DOI：
10.2337/diacare.27.6.1381
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发表时间：
2004-06-01
期刊：
影响因子：
16.2
通讯作者：
Inukai, T
中科院分区：
文献类型：
--
作者：
Aso, Y;Okumura, K;Inukai, T
目的-将三种炎症血液标志物（高敏 C 反应蛋白 [hsCRP]、白细胞介素 [IL]-6 和纤维蛋白原）与动脉粥样硬化性心血管疾病 (CVD) 标志物（中风或心肌缺血史以及测量的趾臂指数 [TBI]）进行比较，以确定炎症标志物是否与 2 型糖尿病患者的动脉粥样硬化相关。 研究设计和方法- 103 名 2 型糖尿病患者中，26 名患有 CVD。 TBI 是通过体积描记法测定两个大脚趾的。采用免疫比浊法测定血清 hsCRP。采用酶联免疫法测定血浆IL-6。 结果：合并CVD的糖尿病患者的ABI和TBI均低于无CVD患者（分别为1.05±0.19 vs.1.14±0.09，P < 0.05；0.75±0.20 vs. 0.95±0.21，P < 0.001）。通过线性回归，右侧TBI而非右侧ABI与血清hsCRP（r = -0.372，P < 0.01）和血浆纤维蛋白原（r = -0.224，P < 0.05）呈显着负相关。血清 hsCRP 也与较低的 TBI 呈负相关，但与较低的 ABI 无关。我们发现血浆 IL-6 与 ABI 或 TBI 之间没有显着相关性。结论 - TBI 与 CVD、血清 hsCRP 和血浆纤维蛋白原密切相关。在这些炎症标志物中，血清 hsCRP 可能是最有希望的血管炎症标志物。
OBJECTIVE- Three blood markers of inflammation (high-sensitivity C-reactive protein [hsCRP], interleukin [IL]-6, and fibrinogen) were compared with markers of atherosclerotic cardiovascular disease (CVD) (history of stroke or cardiac ischemia and measured toe-brachial index [TBI]) to determine whether inflammatory markers are associated with atherosclerosis in patients with type 2 diabetes.RESEARCH DESIGN AND METHODS - Of 103 patients with type 2 diabetes, 26 had CVD. TBI was plethysmographically determined in both great toes. Serum hsCRP was immunonephelometrically determined. Plasma IL-6 was measured by an enzyme immunoassay.RESULTS - Both ABI and TBI were lower in diabetic patients with CVD than in those without CVD(1.05 +/- 0.19 vs.1.14 +/- 0.09, P < 0.05, and 0.75 +/- 0.20 vs. 0.95 +/- 0.21, P < 0.001, respectively). By linear regression, right TBI but not right ABI showed a significant negative correlation with serum hsCRP (r = -0.372, P < 0.01) and plasma fibrinogen (r = -0.224, P < 0.05). Serum hsCRP was also negatively correlated with lower TBI, but not lower ABI. We found no significant correlation between plasma IL-6 and ABI or TBI.CONCLUSIONS- TBI was strongly associated with CVD, serum hsCRP, and plasma fibrinogen. Of these inflammatory markers, serum hsCRP may be the most promising barker for vascular inflammation.