Assessment of Artificial Liver Support Technology
Assessment of Artificial Liver Support Technology
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DOI：
10.1177/096368979200100501
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发表时间：
1992-09
影响因子：
3.3
通讯作者：
M. Yarmush;J. C. Dunn;R. Tompkins
中科院分区：
文献类型：
--
作者：
M. Yarmush;J. C. Dunn;R. Tompkins
尽管经过30多年的研究和开发，人工肝仍然没有成为临床现实。尽管先前尝试使用多种技术（包括血液透析、血液灌流、血浆置换、体外灌注和交叉血液透析）对急性肝功能衰竭患者的疗效略有改善，但有限的临床试验未能证明任何生存获益。受维持肝细胞长期培养的技术进展的鼓舞，最近的努力已经针对使用肝细胞作为肝脏支持的基础。本文回顾了人工肝支持发展的过去和现在的概念，并定性和定量地评估了现有方法的优点和缺点。
Despite more than 30 yr of research and development, an artificial liver has still not yet become clinical reality. Although previous attempts using a multiplicity of techniques including hemodialysis, hemoperfusion, plasma exchange, extracorporeal perfusion, and crosshemodialysis have shown minor improvement in patients with acute hepatic failure, limited clinical trials have failed to demonstrate any survival benefit. Encouraged by the progress on techniques that maintain long-term cultures of hepatocytes, more recent efforts have been directed at the use of hepatocytes as the basis of liver support. This review takes a critical look at past and present concepts in the development of artificial liver supports and both qualitatively and quantitatively evaluates the advantages and disadvantages of the available methodology.