The Effect of Fructose on Renal Biology and Disease
The Effect of Fructose on Renal Biology and Disease
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DOI：
10.1681/asn.2010050506
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发表时间：
2010-12-01
影响因子：
13.6
通讯作者：
Nakagawa, Takahiko
中科院分区：
文献类型：
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作者：
Johnson, Richard J.;Gabriela Sanchez-Lozada, L.;Nakagawa, Takahiko
饮食中果糖的摄入量正在增加。它的增加主要来自添加糖，包括蔗糖和高果糖玉米糖浆，并与全球代谢综合征和高血压患病率的上升有关。给动物和人类服用果糖会增加血压和代谢综合征的发展。这些变化的发生与热量摄入无关，因为果糖对ATP消耗和尿酸生成的影响。果糖摄入也可能是动物肾脏疾病的危险因素，包括肾小球高血压、肾脏炎症和肾小管间质损伤。我们建议过量摄入果糖应被视为一种具有重大健康影响的环境毒素。
Dietary fructose intake is increasing. It is increasing primarily from added sugars, including sucrose and high fructose corn syrup, and correlates epidemiologically with the rising prevalence of metabolic syndrome and hypertension worldwide. The administration of fructose to animals and humans increases BP and the development of metabolic syndrome. These changes occur independently of caloric intake because of the effect of fructose on ATP depletion and uric acid generation. Fructose ingestion may also be a risk factor for kidney disease that includes glomerular hypertension, renal inflammation, and tubulointerstitial injury in animals. We suggest excessive fructose intake should be considered an environmental toxin with major health implications.