Treatment of naming in nonfluent aphasia through manipulation of intention and attention: A phase 1 comparison of two novel treatments
Treatment of naming in nonfluent aphasia through manipulation of intention and attention: A phase 1 comparison of two novel treatments
复制标题
DOI：
10.1017/s1355617707070737
复制
发表时间：
2007-07-01
影响因子：
2.6
通讯作者：
Gonzalez Rothi, Leslie J.
中科院分区：
文献类型：
--
作者：
Crosson, Bruce;Fabrizio, Katherine S.;Gonzalez Rothi, Leslie J.
23例慢性非流利性失语症患者有中度或重度词语发现障碍，1例有重度词语发现障碍，接受两种新的图片命名治疗。意向治疗以复杂的左手运动启动图片命名试验，旨在增强单词检索时的右额叶参与。注意治疗要求患者在其左脑半球观看图片命名试验的视觉刺激，并旨在增强单词检索过程中右脑后侧的参与。由于意图治疗涉及动作机制，而非流利失语反映了启动或维持动作（即语言输出）的困难，因此假设该治疗的意图成分比注意成分更能增强图片命名的再习得。中度和重度文字发现障碍的患者在两种治疗中都表现出获益，但从一个治疗阶段到下一个治疗阶段的增量改善比注意力治疗更大。因此，在这些患者中，意向成分比注意成分更活跃的假设得到了证实。重度语言发现障碍患者在两种治疗方法下均有一定改善，但在意向治疗中无差异效果。几乎所有在任何一种治疗中表现出治疗效果的患者也表现出从训练到未训练项目的泛化。
Twenty-three chronic nonfluent aphasia patients with moderate or severe word-finding impairments and I I with profound word-finding impairments received two novel picture-naming treatments. The intention treatment initiated picture-naming trials with a complex left-hand movement and was designed to enhance right frontal participation during word retrieval. The attention treatment required patients to view visual stimuli for picture-naming trials in their left hemispace and was designed to enhance right posterior perisylvian participation during word retrieval. Because the intention treatment addressed action mechanisms and nonfluent aphasia reflects difficulty initiating or maintaining action (i.e., language output), it was hypothesized that intention component of the treatment would enhance re-acquisition of picture naming more than the attention component. Patients with moderate and severe word-finding impairment showed gains with both treatments but greater incremental improvement from one treatment phase to the next with the intention than the attention treatment. Thus, the hypothesis that intention component would be a more active constituent than the attention component was confirmed for these patients. Patients with profound word-finding impairment showed some improvement with both treatments but no differential effects for the intention treatment. Almost all patients who showed treatment gains on either treatment also demonstrated generalization from trained to untrained items.