STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND
STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND
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DOI：
10.1038/369533a0
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发表时间：
1994-06-16
期刊：
影响因子：
64.8
通讯作者：
EATON, DL
中科院分区：
文献类型：
--
作者：
DESAUVAGE, FJ;HASS, PE;EATON, DL
生理性血小板合成被认为需要meg-CSF和血小板生成素的体液活性，其分别促进巨核细胞的增殖和成熟。一种存在于辐照猪血浆中的meg-CSF/血小板生成素样蛋白已被纯化和克隆。这种蛋白质结合并激活c-mpl蛋白，c-mpl蛋白是细胞因子受体超家族的成员。分离的Mpl配体与促红细胞生成素具有同源性，并刺激巨核细胞生成和血小板生成。
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.