A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
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DOI：
10.1093/hmg/ddr301
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发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Matsuda, Koichi
中科院分区：
文献类型：
--
作者：
Mbarek, Hamdi;Ochi, Hidenori;Matsuda, Koichi
乙型肝炎病毒（HBV）感染是世界范围内的主要健康问题，可导致肝功能障碍、肝硬化和肝细胞癌。为了确定与慢性乙型肝炎（CHB）易感性相关的宿主遗传因素，我们之前进行了一项两阶段全基因组关联研究（GWAS），并确定了亚洲人HLA-DP变异与CHB的关联；然而，使用全基因组单核苷酸多态性（SNP）阵列对179例病例和934例对照进行了基因分型。在这里，我们对458名日本CHB病例和2056名对照进行了519747个snp的第二次GWAS。在与先前鉴定的HLA-DP位点（rs9277535）的变异进行调整后，我们检测到16个位点与p值的强相关性
Hepatitis B virus (HBV) infection is a major health issue worldwide which may lead to hepatic dysfunction, liver cirrhosis and hepatocellular carcinoma. To identify host genetic factors that are associated with chronic hepatitis B (CHB) susceptibility, we previously conducted a two-stage genome-wide association study (GWAS) and identified the association of HLA-DP variants with CHB in Asians; however, only 179 cases and 934 controls were genotyped using genome-wide single nucleotide polymorphism (SNP) arrays. Here, we performed a second GWAS of 519 747 SNPs in 458 Japanese CHB cases and 2056 controls. After adjustment with the previously identified variants in the HLA-DP locus (rs9277535), we detected strong associations at 16 loci with P-value of