Photosensitivity and hyperpigmentation in amiodarone-treated patients: incidence, time course, and recovery.
Photosensitivity and hyperpigmentation in amiodarone-treated patients: incidence, time course, and recovery.
复制标题
胺碘酮治疗患者的光敏性和色素沉着过度：发生率、时程和恢复。
DOI：
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发表时间：
1989
影响因子：
6.5
通讯作者：
K. Wolff
中科院分区：
文献类型：
--
作者：
Kiemens Rappersberger;Herbert Hönigsmann;Bernhard Ortel;A. Tanew;Klaus Konrad;K. Wolff
胺碘酮(AD)在接受该药物治疗的患者中诱导75%的光敏反应。UVA可以在实验中引发光毒反应，但UVB不能。治疗12个月后，UVA-MED显著降低。感光性的发展依赖于AD的总剂量；40g是最小累积剂量要求。在常用的方案下，在连续4个月的AD治疗后，光敏性是可以预期的，并且似乎与皮肤类型无关。阿尔茨海默病停药后4-12个月，光敏性逐渐降低并恢复正常。在平均20个月的持续AD治疗后，大约8%的患者(主要是I型皮肤)出现与AD相关的色素沉着，最小总剂量为160g AD。对没有AD变色的患者暴露在阳光下的皮肤进行电子显微镜检查，发现色素沉积与AD患者暴露和非暴露皮肤中的色素沉着类似。对临床光敏性和非光敏性患者暴露在阳光下的皮肤进行光镜和电子显微镜检查，发现即使在没有临床皮疹的情况下，血管周围也有炎症。在有或没有UVA光敏症的患者中，暴露在阳光下的皮肤中都会出现血管基膜的重复，但在非暴露的皮肤中则没有。在一名患者中，在停药后33个月的随访中，发现AD引起的大量色素沉着是可逆的。
Amiodarone (AD) induces photosensitivity in 75% of the patients treated with this drug. Phototoxic reactions can be experimentally elicited with UVA but not with UVB. The UVA-MED is significantly reduced after 12 months of treatment. The development of photosensitivity depends on the total dose of AD; 40 g is the minimal cumulative dose requirement. Under the regimens commonly used, photosensitivity can be expected after 4 months of continuous AD treatment and appears to be unrelated to the skin type. Photosensitivity gradually decreases and returns to normal between 4 and 12 months after the withdrawal of AD. AD-related hyperpigmentation develops after an average of 20 months of continuous AD treatment and a minimal total dose of 160 g AD in about 8% of the patients (mainly of skin type I). Electron microscopic examination of the sun-exposed skin of patients without AD discoloration shows pigment deposits similar to those already described in patients with AD hyperpigmentation in exposed and non-exposed skin. Light and electronmicroscopic examination of sun-exposed skin of both clinically photosensitive and non-photosensitive patients reveals perivascular inflammation even in the absence of a clinical rash. Reduplications of vascular basal laminae occur in sun-exposed skin of both patients with and without UVA photosensitivity but are absent from non-exposed skin. In one patient, followed for 33 months after drug withdrawal, massive AD-induced hyperpigmentation was found to be reversible.
胺碘酮和去乙基胺碘酮对大鼠肺溶酶体磷脂酶 A1 的体外抑制作用。
DOI：
10.1016/0005-2760(88)90205-6
发表时间：
1988
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Hostetler,KY;Giordano,JR;Jellison,EJ
通讯作者：
Jellison,EJ