Association of the catechol-O-methyltransferase polymorphism with methylphenidate response in a classroom setting in children with attention-deficit hyperactivity disorder
Association of the catechol-O-methyltransferase polymorphism with methylphenidate response in a classroom setting in children with attention-deficit hyperactivity disorder
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DOI：
10.1097/yic.0b013e328306a977
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发表时间：
2008-09-01
影响因子：
2.6
通讯作者：
Cho, Dae-Yeon
中科院分区：
文献类型：
--
作者：
Cheon, Keun-Ah;Jun, Jin-Yong;Cho, Dae-Yeon
人们一直认为前额皮质在注意力缺陷多动障碍（ADHD）中起着关键作用。儿茶酚- o -甲基转移酶（COMT）酶降解突触儿茶酚胺，并在前额皮质多巴胺的分解代谢中发挥特定作用。我们研究了COMT缬氨酸（Val） 108/158蛋氨酸（Met）多态性与ADHD儿童对哌醋甲酯（MPH）治疗的反应之间的关系。这项研究包括韩国124名患有多动症的儿童。与治疗前的基线ADHD评定量表评分相比，治疗8周后改善大于或等于50%的患者被认为是“良好反应”组。在对COMT进行基因分型后，我们使用X检验检查了COMT多态性2与MPH治疗反应的相关性。我们发现，62.5%对MPH治疗反应良好的患者为Val/Val基因型，而41.7%和11.7%的对MPH治疗反应较差的患者为Val/Met和Met/Met基因型（chi(2) = 6.58, d.f = 2, P = 0.035）。我们的研究结果为COMT基因型和MPH反应之间的关联提供了证据，这是由ADHD儿童的教师评估的。
It has been postulated that the prefrontal cortex plays a key role in attention-deficit hyperactivity disorder (ADHD). The catechol-O-methyltransferase (COMT) enzyme degrades synaptic catecholamines and plays a specific role in the catabolism of prefrontal cortex dopamine. We investigated the association between the COMT valine (Val) 108/158 methionine (Met) polymorphism and the response to treatment with methylphenidate (MPH) in children with ADHD. This study included 124 children with ADHD in South Korea. Those patients who had an improvement after 8 weeks of treatment greater than or equal to 50% compared with the baseline ADHD rating scale scores before treatment were considered to be the 'good response' group. After performing genotyping for COMT, we examined the correlation of the COMT polymorphism 2 with response to treatment with MPH using the X test. We found that whereas 62.5% of the patients showing a good response to MPH treatment had the Val/Val genotype, 41.7 and 11.7% of the patients showing a poor response to MPH treatment as assessed by their teachers had the Val/Met and Met/Met genotypes (chi(2) = 6.58, d.f. = 2, P = 0.035). Our findings provide evidence of an association between the COMT genotype and MPH response as assessed by the teachers of children with ADHD.