Thiazide diuretics exacerbate fructose-induced metabolic syndrome
Thiazide diuretics exacerbate fructose-induced metabolic syndrome
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DOI：
10.1681/asn.2007040416
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发表时间：
2007-10-01
影响因子：
13.6
通讯作者：
Nakagawa, Takahiko
中科院分区：
文献类型：
--
作者：
Reungjui, Sirirat;Roncal, Carlos A.;Nakagawa, Takahiko
果糖是一种常用的甜味剂，与增加代谢综合征患病率的饮食有关。噻嗪类利尿剂常用于这些患者治疗高血压，但它们也会加重代谢综合征。给予噻嗪类高果糖饮食的大鼠表现出钾耗竭和高尿酸血症。钾补充剂改善了他们的胰岛素抵抗和高血压，而别嘌呤醇降低了血清尿酸水平，改善了高血压、高血糖症、高血糖症和胰岛素抵抗。补钾和别嘌呤醇治疗也增加尿一氧化氮排泄。我们认为，大鼠钾耗竭和高尿酸血症加剧内皮功能障碍，降低一氧化氮的生物利用度，从而阻断胰岛素活性，并导致胰岛素抵抗在噻嗪使用。补充钾和别嘌呤醇与噻嗪类药物可能有助于代谢综合征的管理。
Fructose is a commonly used sweetener associated with diets that increase the prevalence of metabolic syndrome. Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome. Rats on high-fructose diets that are given thiazides exhibit potassium depletion and hyperuricemia. Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance. Both potassium supplementation and treatment with allopurinol also increase urinary nitric oxide excretion. We suggest that potassium depletion and hyperuricemia in rats exacerbates endothelial dysfunction and lowers the bioavailability of nitric oxide, which blocks insulin activity and causes insulin resistance during thiazide usage. Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome.