Biogenic green synthesis of MgO nanoparticles usingSaussurea costusbiomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials
Biogenic green synthesis of MgO nanoparticles usingSaussurea costusbiomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials
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DOI：
10.1371/journal.pone.0237567
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发表时间：
2020-08-14
期刊：
影响因子：
3.7
通讯作者：
Moubayed, Nadine M. S.
中科院分区：
文献类型：
--
作者：
Amina, Musarat;Al Musayeib, Nawal M.;Moubayed, Nadine M. S.
以木香根生物质为原料合成了不同形貌的氧化镁纳米颗粒（MgONP）。以两个不同品种的风毛菊（Qustal hindi和Qustal bahri）为原料，采用绿色合成法制备了MgONP。纳米粒子的物理和化学特征，通过光谱和显微镜技术进行了确认。通过SEM和TEM显微镜在不同的放大倍数下检测所获得的纳米颗粒的表面形态，发现对于Qustal hindi和Qustal bahri，纳米颗粒的尺寸分别为30和34 nm。制备的MgONP的抗菌活性进行了筛选，对6种致病菌。由Qustal bahri生物质合成的纳米颗粒对大肠杆菌、铜绿假单胞菌、热带念珠菌和光滑念珠菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌圈分别为15、16、18、17、14和10 mm，而来自Qustal hindi的纳米颗粒对枯草芽孢杆菌、大肠杆菌和热带念珠菌的抑菌圈分别为12、8和17 mm。MgONP对MCF-7乳腺癌细胞系显示出潜在的细胞毒性作用。MgONP的细胞研究显示，由Qustal bahri制备的纳米颗粒对MCF-7癌细胞系表现出高细胞毒性。对MCF-7细胞的IC（50）值分别为67.3%和52.1%。并对不同品种的雪莲果MgONP的光催化活性进行了比较研究。紫外光照射1h后，它们对亚甲基蓝的光催化降解率增强，由Qustal bahri和Qustal hindi制备的催化剂分别为92%和59%。结果表明，生物合成的MgONPs显示出良好的生物医学潜力。
Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses ofSaussurea costusroots. The biomass of two varieties ofSaussurea costus(Qustal hindi and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical features of nanoparticles were confirmed by spectroscopic and microscopic techniques. The surface morphology of the obtained nanoparticles was detected at different magnifications by SEM and TEM microscopy and the size of nanoparticles were found to be 30 and 34 nm for Qustal hindi and Qustal bahri, respectively. The antimicrobial activity of the prepared MgONPs was screened against six pathogenic strains. The synthesized nanoparticles by Qustal bahri biomass exerted significant inhibition zones 15, 16, 18, 17, 14, and 10 mm againstE.coli,P.aeruginosa,C.tropicalisandC.glabrata,S.aureusandB.subtilisas compared to those from Qustal hindi 12, 8 and 17 mm againstB.subtilis,E.coliandC.tropicalis, respectively. MgONPs showed a potential cytotoxicity effect against MCF-7 breast cancer cell lines. Cellular investigations of MgONPs revealed that the prepared nanoparticles by Qustal bahri exhibited high cytotoxicity against MCF-7 cancer cell lines. IC(50)values in MCF-7 cells were found to be 67.3% and 52.1% for MgONPs ofSaussurea costusbiomasses, respectively. Also, the photocatalytic activity of MgONPs of eachSaussurea costusvariety was comparatively studied. They exhibited an enhanced photocatalytic degradation of methylene blue after UV irradiation for 1 h as 92% and 59% for those prepared by Qustal bahri and Qustal hindi, respectively. Outcome of results revealed that the biosynthesized MgONPs showed promising biomedical potentials.