Feasible temperature of percutaneous microwave ablation of dog liver abutting the bowel
Feasible temperature of percutaneous microwave ablation of dog liver abutting the bowel
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DOI：
10.3109/02656736.2010.508763
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发表时间：
2011-03
影响因子：
3.1
通讯作者：
Qiujie Shao;Z. Han;Xiao-xia Ni;W. Shi;Yuan-yuan Sun;Hong Liu;L. Xin;L. Ping
中科院分区：
文献类型：
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作者：
Qiujie Shao;Z. Han;Xiao-xia Ni;W. Shi;Yuan-yuan Sun;Hong Liu;L. Xin;L. Ping
目的：本研究通过狗模型确定经皮微波消融术的最佳温度，微波消融术引起肝脏完全坏死，但不引起邻近肠完全坏死，支持使用该方法特异性有效治疗邻近肠的肝肿瘤。材料与方法：对健康成年犬进行超声引导下经皮肝近肠微波消融术。通过插入热监测针对烧蚀边缘温度进行监测和控制。将犬分为三组，分别在75 ~ 95℃、65 ~ 75℃、55 ~ 65℃进行微波消融。影像学和组织学检查评估切除肝旁肠的损伤情况。结果：75 ~ 95℃微波消融术组在治疗1小时内，消融肝旁肠严重烧伤。65 ~ 75℃微波消融术组肠黏膜下层出现炎症和充血。55 ~ 65℃微波消融术组肠黏膜出现轻微炎症。55 ~ 65℃微波消融术组肝脏消融区可见大网膜覆盖，消融术后28天组织学检查显示大网膜出现炎症反应。结论：55 ~ 65℃微波消融术治疗犬近肠肝组织的效果较好。本研究结果可为经皮微波消融术治疗邻近肠道的人肝脏肿瘤提供参考。
Purpose: This study used a dog model to determine the optimal temperature of percutaneous microwave ablation that causes complete necrosis of liver but not the adjacent bowel, supporting the use of this method to specifically and effectively treat liver tumour abutting the bowel. Materials and methods: Ultrasound-guided percutaneous microwave ablation of liver abutting the bowel was performed on healthy adult dogs. Temperature of the ablation margin was monitored and controlled through inserted thermal monitoring needles. Dogs were divided into three groups and received microwave ablation at 75–95°C, 65–75°C, or 55–65°C. Imaging and histological examination were used to evaluate the damage of the bowel adjacent to the ablated liver. Results: Within one hour of treatment, the bowel adjacent to the ablated liver was seriously burned in the group receiving 75–95°C microwave ablation. Inflammation and congestion were found in the submucosa of the bowel in the group receiving 65–75°C microwave ablation. Minor inflammation was found in the mucosa of the bowel in the group receiving 55–65°C microwave ablation. Moreover, in the group receiving 55–65°C microwave ablation, ablated liver areas were covered with omenta, and histological examination revealed inflammatory reaction of the omenta 28 days after ablation. Conclusions: Microwave ablation at 55–65°C for 6 min is preferred for ablation of liver tissue abutting the bowel in dogs. These findings may provide some valuable reference for percutaneous microwave ablation of human liver tumour adjacent to the bowel.