Glucose metabolism in man: responses to intravenous glucose infusion.
Glucose metabolism in man: responses to intravenous glucose infusion.
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人类的葡萄糖代谢：对静脉注射葡萄糖的反应。
DOI：
10.1016/0026-0495(79)90066-0
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
John F. Burke
中科院分区：
文献类型：
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作者：
Robert R. Wolfe;J. R. Allsop;John F. Burke
我们通过同时启动恒定输注 6-3 H 和 U-13 C-葡萄糖，确定了未标记的葡萄糖输注（添加或不添加胰岛素）对正常男性志愿者葡萄糖代谢的影响。输注 90 分钟后测量葡萄糖动力学。当达到稳定状态时，内源性葡萄糖的产生（2.53±058mg/kg·min，X±SEM）在所有测试的外源性葡萄糖速率（1、2和4mg/kg·min）下均受到抑制。在最高输注速率时绝对抑制程度最显着（75%），但相对于输注速率而言最大程度的抑制是在最低输注速率时。葡萄糖输注期间血浆葡萄糖浓度的控制主要通过调节内源性Ra来实现。尽管在2mg/kg·min输注期间血浆葡萄糖和胰岛素浓度也显着升高，但葡萄糖的摄取率仅在4mg/kg·min输注期间增加。仅当通过4mg/kg·min葡萄糖输注来输注足够的胰岛素以控制不施用胰岛素时发生的高血糖时，葡萄糖清除率才会增加。当输注速率为1或2 mg/kg·min时，大约43%的输注葡萄糖被直接氧化。当输注速度增加至4 mg/kg·min 时，无论是否输注胰岛素，该值均下降至32%。
We have determined the effect of unlabeled glucose infusions, with and without added insulin, on glucose metabolism in normal male volunteers by means of the simultaneous primed-constant infusion of 6-3 H and U-13 C-glucose. Glucose kinetics were measured after 90 min of infusion. When steady state had been reached, endogenous glucose production (2.53±. 058 mg/kg· min, X±SEM) was suppressed at all rates of exogenous glucose tested (1, 2, and 4 mg/kg· min). The absolute degree of suppression was most marked (75%) at the highest rate of infusion, but the greatest degree of suppression, relative to infusion rate, was at the lowest infusion rate. The control of plasma glucose concentration during the glucose infusion was achieved primarily through regulation of endogenous Ra. The rate of uptake of glucose only increased during the 4 mg/kg· min infusion, even though there were significant elevations in the plasma glucose and insulin concentrations during the 2 mg/kg· min infusion as well. The glucose clearance rate increased only when sufficient insulin was infused with the 4 mg/kg· min glucose infusion to control the hyperglycemia that developed if no insulin was administered. Approximately 43% of the infused glucose was directly oxidized when the infusion rate was 1 or 2 mg/kg· min. That value fell to 32% when the infusion rate was increased to 4 mg/kg· min, regardless of whether insulin was infused or not.