The KiSS1/GPR54 system in fish
The KiSS1/GPR54 system in fish
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DOI：
10.1016/j.peptides.2008.08.018
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发表时间：
2009-01-01
期刊：
影响因子：
3
通讯作者：
Elizur, Abigail
中科院分区：
文献类型：
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作者：
Elizur, Abigail
KiSS 1/GPR 54系统现已在非哺乳类脊椎动物中鉴定。编码KiSS 1及其受体GPR 54的转录本已从许多鱼类中分离出来。其基因的表达的特点是在时间和空间表达的背景下，并在响应内分泌操作。GPR 54序列在哺乳动物和鱼类之间是保守的，在斑马鱼中鉴定出第二个受体序列。KiSS 1基因序列在哺乳动物和鱼类之间存在高度差异，但人类kisspeptin能够激活鱼类GPR 54。与哺乳动物一样，鱼类KiSS 1/GPR 54系统似乎部分受性腺类固醇调节。现有的鱼类数据是零散的，但表明KiSS 1/GPR 54系统在非哺乳类脊椎动物中功能保守，并支持其在鱼类系统中的青春期发育和生殖中发挥作用的观点。(C)2008年爱思唯尔公司版权所有
The KiSS1/GPR54 system has now been identified in non-mammalian vertebrates. Transcripts encoding for KiSS1 and its receptor, GPR54, have been isolated from a number of fish species. The expression of their genes was characterized in the context of temporal and spatial expression and in response to endocrine manipulations. GPR54 sequence is conserved between mammals and fish, with a second receptor sequence identified in zebrafish. The KiSS1 gene sequence is highly divergent between mammals and fish, yet the human kisspeptin is capable of activating the fish GPR54. As in mammals, the fish KiSS1/GPR54 system appears to be partially regulated by gonadal steroids. The data available for fish are fragmented, yet indicate that the KiSS1/GPR54 system is functionally conserved in non-mammalian vertebrates and supports the notion that it has a role in pubertal development and reproduction in piscine systems. (C) 2008 Elsevier Inc. All rights reserved