Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease
Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease
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DOI：
10.1016/s0925-4439(96)00056-7
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发表时间：
1996-12-16
影响因子：
6.2
通讯作者：
Aerts, JMFG
中科院分区：
文献类型：
--
作者：
Michelakakis, H;Spanou, C;Aerts, JMFG
测定了不同类型戈谢病（GD）患者和其他溶酶体贮积病患者血浆中肿瘤坏死因子-a（TNF-α）水平。在最严重的神经元病型GD中观察到最高的TNF-α水平，超过了在健康个体以及患有其他溶酶体疾病的患者中发现的水平。I型GD病例显示出范围从正常到2.5倍最高对照值的广泛的TNF-α水平。TNF-α是主要由活化的巨噬细胞产生的多效性细胞因子。我们的数据表明，它可能在GD疾病的病理生理学中发挥作用。
Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.