miR-21: a small multi-faceted RNA.
miR-21: a small multi-faceted RNA.
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DOI：
10.1111/j.1582-4934.2008.00556.x
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发表时间：
2009-01
影响因子：
5.3
通讯作者：
Gabriely G
中科院分区：
文献类型：
--
作者：
Krichevsky AM;Gabriely G
超过1000个microRNAs(MiRNAs)在人类细胞中表达，其中一些是组织或细胞类型特有的，另一些被认为是管家分子。在过去的几年里，对一些miRNAs的功能和直接的mRNA靶标进行了相对较好的研究。每个miRNA都可能调节许多蛋白质编码基因的表达(数十到数百个)，但越来越清楚的是，并不是所有的miRNAs都同样重要；对各种系统的各种高通量筛选一再确定了有限数量的关键功能miRNAs。特定的miRNAs是在各种生理和病理生理环境中控制主要细胞功能的主要调节因子。MiR-21是3年前发现的在人脑胶质母细胞瘤中最常见且上调最强的miRNA，引起了发育、肿瘤学、干细胞生物学和衰老等领域的研究人员的注意，与let-7、miR-17-92簇(oncomiR-1)、miR-155等一起成为研究最多的miRNA之一。然而，miR-21基因敲除小鼠尚未产生，有关miR-21在正常细胞中的功能的数据仍然非常有限。本文综述了miR-21在人类疾病中作用的研究现状，重点介绍了miR-21在人类疾病中的调控、致癌作用、肿瘤靶点、作为疾病生物标志物的潜力以及肿瘤治疗的新靶点。
More than 1000 microRNAs (miRNAs) are expressed in human cells, some tissue or cell type specific, others considered as house-keeping molecules. Functions and direct mRNA targets for some miRNAs have been relatively well studied over the last years. Every miRNA potentially regulates the expression of numerous protein-coding genes (tens to hundreds), but it has become increasingly clear that not all miRNAs are equally important; diverse high-throughput screenings of various systems have identified a limited number of key functional miRNAs over and over again. Particular miRNAs emerge as principal regulators that control major cell functions in various physiological and pathophysiological settings. Since its identification 3 years ago as the miRNA most commonly and strongly up-regulated in human brain tumour glioblastoma, miR-21 has attracted the attention of researchers in various fields, such as development, oncology, stem cell biology and aging, becoming one of the most studied miRNAs, along with let-7, miR-17–92 cluster (‘oncomir-1’), miR-155 and a few others. However, an miR-21 knockout mouse has not yet been generated, and the data about miR-21 functions in normal cells are still very limited. In this review, we summarise the current knowledge of miR-21 functions in human disease, with an emphasis on its regulation, oncogenic role, targets in human cancers, potential as a disease biomarker and novel therapeutic target in oncology.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
11.2
作者：
Corsten, Maarten F.;Miranda, Rafael;Shah, Khalid
通讯作者：
Shah, Khalid
影响因子：
8
作者：
Bitomsky, N;Böhm, M;Klempnauer, KH
通讯作者：
Klempnauer, KH
DOI：
10.1073/pnas.96.24.14037
发表时间：
1999-11-23
影响因子：
11.1
作者：
Cmarik, JL;Min, HZ;Colburn, NH
通讯作者：
Colburn, NH