Continuous theta burst stimulation over left and right supramarginal gyri demonstrates their involvement in auditory feedback control of vocal production
Continuous theta burst stimulation over left and right supramarginal gyri demonstrates their involvement in auditory feedback control of vocal production
复制标题
对左右边缘上回的连续 theta 爆发刺激表明它们参与发声的听觉反馈控制
DOI：
10.1093/cercor/bhac049
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发表时间：
2022-02-17
期刊：
影响因子：
3.7
通讯作者：
Liu, Hanjun
中科院分区：
文献类型：
--
作者：
Li, Tingni;Zhu, Xiaoxia;Liu, Hanjun
边缘上回（SMG）与声音产生的听觉-运动整合有关。然而，SMG是否以因果方式双边或单方面参与声音产生的听觉反馈控制尚不清楚。本研究利用神经导航连续θ波爆发刺激（c-TBS）研究了左、右侧上皮层在听觉-声音整合中的因果作用。24名年轻人产生了持续的元音发音，在接受主动或假c-TBS后，他们的声音出乎意料地发生了+/- 200美分的音高变化。与假刺激相比，c-TBS对左或右SMG的刺激导致音调扰动的声音补偿明显减少，并伴有较小的皮质P2反应。此外，当比较活跃的c-TBS与左、右SMG时，在声音和ERP反应上没有发现显著差异。这些发现为左右侧SMG对声音产生的听觉反馈控制的因果影响提供了神经行为学证据。c-TBS后，双侧SMG上P2反应的减少与声音代偿的减少并行，支持了它们在自下而上的听觉-运动转换中的作用：接收听觉反馈信息并介导对反馈错误的声音代偿。
The supramarginal gyrus (SMG) has been implicated in auditory-motor integration for vocal production. However, whether the SMG is bilaterally or unilaterally involved in auditory feedback control of vocal production in a causal manner remains unclear. The present event-related potential (ERP) study investigated the causal roles of the left and right SMG to auditory-vocal integration using neuronavigated continuous theta burst stimulation (c-TBS). Twenty-four young adults produced sustained vowel phonations and heard their voice unexpectedly pitch-shifted by +/- 200 cents after receiving active or sham c-TBS over the left or right SMG. As compared to sham stimulation, c-TBS over the left or right SMG led to significantly smaller vocal compensations for pitch perturbations that were accompanied by smaller cortical P2 responses. Moreover, no significant differences were found in the vocal and ERP responses when comparing active c-TBS over the left vs. right SMG. These findings provide neurobehavioral evidence for a causal influence of both the left and right SMG on auditory feedback control of vocal production. Decreased vocal compensations paralleled by reduced P2 responses following c-TBS over the bilateral SMG support their roles for auditory-motor transformation in a bottom-up manner: receiving auditory feedback information and mediating vocal compensations for feedback errors.