Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies
Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies
复制标题
黄酮醇摄入量与冠心病风险：队列研究的荟萃分析
DOI：
10.1016/j.atherosclerosis.2012.02.026
复制
发表时间：
2012-05-01
期刊：
影响因子：
5.3
通讯作者：
Yang, Zhi-Jian
中科院分区：
文献类型：
--
作者：
Wang, Ze-Mu;Nie, Zhen-Lin;Yang, Zhi-Jian
目的：前瞻性队列关于黄酮醇摄入量与冠心病 (CHD) 风险之间的关系不一致。目的是进行荟萃分析，以确定观察性研究中它们之间是否存在关联。方法：我们检索了 PUBMED 和 EMBASE 数据库，查找从 1966 年到 2012 年 1 月进行的研究。数据由 2 位研究人员使用标准化方案独立提取。使用随机效应模型结合研究特定风险估计。结果：荟萃分析中纳入了总共 9 个一般人群队列，共有 216,908 名参与者和超过 5249 例 CHD 病例。总结相对风险 (RR) 并未表明最高黄酮醇摄入量与降低 CHD 风险之间存在显着关联（总结 RR：0.91；95% CI：0.83，1.01）。此外，通过剂量反应分析未发现显着关联（增加 20 毫克/天，总结 RR：0.96；95% CI：0.90，1.03）。结论：我们的结果不支持黄酮醇摄入对 CHD 的保护作用。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Objective: Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies.Methods: We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model.Results: A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20 mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03).Conclusions: Our results do not support a protective role of flavonols intake against CHD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.