β-Aminosulfonamide-Catalyzed Direct Asymmetric Aldol Reaction in Brine
β-Aminosulfonamide-Catalyzed Direct Asymmetric Aldol Reaction in Brine
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DOI：
10.1055/s-0030-1259317
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发表时间：
2011-02-01
期刊：
影响因子：
2
通讯作者：
Itoh, Akichika
中科院分区：
文献类型：
--
作者：
Miura, Tsuyoshi;Ina, Mariko;Itoh, Akichika
在催化量的β-氨基磺酰胺2和三氟乙酸存在下，在盐水中醛与酮的直接不对称羟醛缩合反应导致以高达96%的对映体过量高产率形成相应的反羟醛缩合产物。使用有机催化剂2得到的反羟醛产物具有与我们以前报道的使用类似的磺酰胺催化剂1得到的反羟醛产物相反的绝对构型。
Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of beta-aminosulfonamide 2 and trifluoroacetic acid in brine results in the formation of the corresponding anti-aldol products in high yields with up to 96% enantiomeric excess. The anti-aldol products obtained by using organocatalyst 2 have the opposite absolute configuration to those obtained using the similar sulfonamide catalyst 1, which was reported previously by us.