RELATIONSHIP OF MATERNAL SUBSTANCE-ABUSE TO SUBSEQUENT SUDDEN-INFANT-DEATH-SYNDROME IN OFFSPRING
RELATIONSHIP OF MATERNAL SUBSTANCE-ABUSE TO SUBSEQUENT SUDDEN-INFANT-DEATH-SYNDROME IN OFFSPRING
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DOI：
10.1016/s0022-3476(05)81554-9
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发表时间：
1993-07-01
影响因子：
5.1
通讯作者：
JESSOP, D
中科院分区：
文献类型：
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作者：
KANDALL, SR;GAINES, J;JESSOP, D
为了评估母亲在怀孕期间吸毒与随后的婴儿猝死综合症 (SIDS) 之间的可能关系，我们从 1979 年至 1989 年间出生于纽约市的超过 120 万婴儿 (1.45/1000) 中确定了 1760 例 SIDS 病例。吸毒婴儿的 SIDS 率为每 1000 名婴儿 5.83 例，而接触药物的婴儿为每 1000 名婴儿 1.39 例。没有接触过药物。在控制已知相关高风险变量的情况下，每个药物组（美沙酮，3.6；海洛因，2.3；美沙酮和海洛因，3.2；可卡因，1.6；可卡因和美沙酮或海洛因，1.1）的 SIDS 风险比高于非药物暴露组。单独接触阿片类药物的婴儿的 SIDS 发生率高于接触可卡因的婴儿，但在本世纪末接触可卡因的婴儿中 SIDS 的发生率不断增加，这表明“强效”可卡因可能与这些增加的比率有关。十年间，药物暴露组（每 1000 人 11.28 至 4.09 人）和非暴露组（每 1000 人 1.70 至 1.05 人）的 SIDS 总体发生率均下降。如果母亲在怀孕期间使用毒品，则主要种族群体之间未接触毒品的婴儿的 SIDS 发生率差异并不明显。 SIDS 死亡时的季节变化和年龄分布在药物暴露组和非暴露组之间没有差异，这表明药物相关的 SIDS 可能为 SIDS 的原因提供线索。
To assess the possible relationship between maternal drug use during pregnancy and subsequent sudden infant death syndrome (SIDS), we identified 1760 cases of SIDS from a population of more than 1.2 million infants (1.45/1000) born in New York City between 1979 and 1989. The SIDS rate in drug-exposed infants was 5.83 per 1000 infants, compared with 1.39 per 1000 infants who were not drug exposed. With control for known associated high-risk variables, the risk ratio for SIDS in each individual drug group (methadone, 3.6; heroin, 2.3; methadone and heroin, 3.2; cocaine, 1.6; cocaine and methadone or heroin, 1.1) was higher than in the non-drug-exposed group. Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that ''crack'' cocaine may be linked to these increasing rates. Declines in the overall rate of SIDS during the decade were observed for both the drug-exposed (11.28 to 4.09 per 1000) and the nonexposed groups (1.70 to 1.05 per 1000). Differences in rates of SIDS between major racial-ethnic groups in nonexposed infants were not apparent if the mothers used drugs during pregnancy. Seasonal variation and distribution of ages at time of SIDS death did not differ between the drug-exposed group and the nonexposed group, suggesting that drug-associated SIDS may provide clues as to the cause or causes of SIDS.