Mechanisms of chromosome behaviour during mitosis.

Mechanisms of chromosome behaviour during mitosis.
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DOI:
10.1038/nrm2832
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发表时间:
2010-02
期刊:
Nature reviews. Molecular cell biology
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世纪以来,科学家们一直致力于了解有丝分裂过程中染色体精确分离的机制。这一过程最有趣的特征是染色体表现出的复杂行为,这在高等真核生物中尤为突出。这种行为是基于染色体和纺锤体微管之间的特异性和高度调节的相互作用。最近的发现,通过高分辨率成像结合各种遗传,分子,细胞生物学和化学工具,支持建立和控制染色体和微管之间的动态相互作用是基因组保真度的主要因素的想法。
For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.
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