Presumed benefit: lessons from the American experience with marrow transplantation for breast cancer
Presumed benefit: lessons from the American experience with marrow transplantation for breast cancer
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DOI：
10.1136/bmj.324.7345.1088
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发表时间：
2002-05-04
影响因子：
105.7
通讯作者：
Mogielnicki, J
中科院分区：
文献类型：
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作者：
Welch, HG;Mogielnicki, J
在医学界，很少有故事像美国人用自体骨髓移植(ABMT)治疗乳腺癌那样发人深省。这是一个年轻女性死于侵袭性疾病的故事，善意的医生试图同样积极地治疗这种疾病，律师们辩称，保险公司应该买单。这也是一个关于专业利益、薄弱的研究、经济利益、政治和欺诈的故事。由于它与目前正在开发的复杂癌症疗法(如基因疗法)有潜在的相关性，我们在这里讲述这个故事和它的教训。
Few stories in medicine are as sobering as the American experience with autologous bone marrow transplantation (ABMT) for treating breast cancer. It is a story of young women dying from aggressive disease, well meaning physicians trying to be equally aggressive in treating it, and lawyers arguing that insurers should pay the bill. It is also a story of professional interests, weak research, financial gain, politics, and fraud. Because of its potential relevance to complex cancer therapies currently in development (such as gene therapy) we recount here the story and its lessons.