Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens
Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens
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DOI：
10.1016/s0166-6851(97)00065-0
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发表时间：
1997-08-01
影响因子：
1.5
通讯作者：
Langsley, G
中科院分区：
文献类型：
--
作者：
Barale, JC;AttalBonnefoy, G;Langsley, G
本文描述了一种新的恶性疟原虫抗原——天冬酰胺和天冬氨酸富蛋白2 (PfAARP2)，其长度为150 kDa，由1号染色体上的一个独特基因编码。PfAARP2在侵染后12 h首次表达，并在滋养体和分裂体中积累。免疫荧光研究表明PfAARP2易位到红细胞细胞质中。Pfaarp2的中心区域包含编码天冬酰胺和天冬氨酸残基的重复片段，这定义了一个分散在不同染色体上的新相关基因家族，该家族的两个成员也已被确定。有趣的是，PfAARP2的非重复N端和c端与酵母和人类预测的两种蛋白具有显著的相似性，并讨论了其可能的功能。(C) 1997爱思唯尔科学有限公司
We describe here a new Plasmodium falciparum antigen, asparagine and aspartate rich protein 2 (PfAARP2) of 150 kDa, which is encoded by a unique gene on chromosome 1. PfAARP2 is first expressed 12 h post-invasion and accumulates in trophozoites and schizonts. Immunofluorescence studies indicate that PfAARP2 is translocated into the red blood cell cytoplasm. The central region of Pfaarp2 contains blocks of repetitions encoding asparagine and aspartate residues, which define a new family of related genes dispersed on different chromosomes, and two members of this family have also been identified. Interestingly, the non-repeated N- and C-termini of PfAARP2 display significant similarity to two yeast and human predicted proteins, and its possible function is discussed. (C) 1997 Elsevier Science B.V.