Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight.
Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight.
复制标题
血管紧张素转换酶基因的插入/缺失多态性影响心脏重量。
作者：
Ken;Satoru Matsushita;Hiroko Matsuoka;Takashi Inamatsu;Masanori Nishinaga;Masahiko Yonawa;Tadashi Aono;T. Arai;Yukiyoshi Ezaki;Hajime Orimo
背景
血管紧张素II（Angiotensin II，Ang II）是左心室质量的主要调节因子，由血管紧张素I（AngI）经血管紧张素转换酶（ACE）作用产生。ACE水平与ACE基因的插入/缺失（I/D）多态性相关。ACE基因多态性会导致不同的血管紧张素II浓度，从而影响左心室质量。因此，我们研究了ACE基因型是否是心脏重量的预测因子。
方法和结果
从1994年至1998年在我院进行尸检的693例连续患者中，排除了瓣膜病、心肌梗死或心肌病患者。其余443例尸检患者是我们研究的对象。尸检时的心脏重量根据体表面积进行了校正。从肾脏中纯化基因组DNA，并通过聚合酶链反应确定ACE基因型。DD基因型的心脏重量（249。9+/-49.9 g/m2）显著高于ID（230. 0+/-51.2g/m2; P<0.05）和II（226.8+/-49.8g/m2; P<0.01）基因型。心脏重量与年龄（r=0.145，P<0.0001）和冠状动脉狭窄指数（r=0.147，P=0.0019）呈正相关。多元回归分析显示，高血压病史（P<0.0001）、年龄（P=0.0001）和DD基因型（P=0.0154）是心脏重量的独立预测因素。
结论
ACE基因型预测心脏质量，但是，它不如高血压或年龄等表观遗传因素有效。
BACKGROUND
Angiotensin (Ang) II, a major regulatory factor for left ventricular mass, is generated from Ang I by ACE. ACE levels are associated with an insertion/deletion (I/D) polymorphism in the ACE gene. The ACE polymorphism should result in varied Ang II concentrations and hence affect left ventricular mass. We therefore investigated whether ACE genotype is a predictor of heart weight.
METHODS AND RESULTS
From 693 consecutive patients autopsied between 1994 and 1998 in our hospital, patients with valvular disease, myocardial infarction, or cardiomyopathy were excluded. The remaining 443 autopsy patients were the subjects of our study. The heart weight at autopsy was corrected for body surface area. Genomic DNA was purified from the kidney, and ACE genotype was determined by polymerase chain reaction. Heart weight in the DD genotype (249. 9+/-49.9 g/m(2)) was significantly higher than that in the ID (230. 0+/-51.2 g/m(2); P<0.05) and II (226.8+/-49.8 g/m(2); P<0.01) genotypes. Heart weight was also positively related to age (r=0.145, P<0.0001) and coronary stenosis index (r=0.147, P=0.0019). Multiple regression analysis showed that a history of hypertension (P<0.0001), age (P=0.0001), and DD genotype (P=0.0154) were independent predictors of heart weight.
CONCLUSIONS
ACE genotype predicts cardiac mass; however, it was less effective than epigenetic factors such as hypertension or age.
影响因子：
9.8
作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier
通讯作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier
DOI：
10.1073/pnas.95.23.13893
发表时间：
1998-11-10
影响因子：
11.1
作者：
Mende, U;Kagen, A;Neer, EJ
通讯作者：
Neer, EJ