Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate.
Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate.
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DOI：
10.18632/aging.100416
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Sell C
中科院分区：
文献类型：
--
作者：
Lorenzini A;Fink LS;Stamato T;Torres C;Sell C
我们研究了纺锤体组装检查点（SAC）的耐受性，通过在微管抑制剂存在下的四倍体细胞的外观来测量，在一系列来自不同寿命和体型的物种的原代细胞株中。我们发现SAC的完整性在这些物种中有所不同。SAC的完整性与体型之间有很强的相关性，但与寿命和物种发育参数（即雌性受孕时间、妊娠长度和产后生长速度）的相关性较差。结果表明，SAC的保真度与达到成年所需的有丝分裂数量的关系比与物种寿命的关系更密切。
We have examined the tolerance of the spindle assembly checkpoint (SAC), as measured by the appearance of tetraploid cells in the presence of a microtubule inhibitor, in a series of primary cell strains derived from species with diverse lifespan and body size. We find that the integrity of the SAC varies among these species. There is a robust correlation between the integrity of the SAC and body size, but poor correlation with longevity and parameters of species development (i.e., time of female fertility, gestation length, and postnatal growth rate). The results suggest that fidelity of the SAC co-evolved more closely with the number of mitoses needed to reach adulthood than with species lifespan.