The Spatial Periodicity of Grid Cells Is Not Sustained During Reduced Theta Oscillations
The Spatial Periodicity of Grid Cells Is Not Sustained During Reduced Theta Oscillations
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DOI：
10.1126/science.1201685
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发表时间：
2011-04-29
期刊：
影响因子：
56.9
通讯作者：
Leutgeb, Stefan
中科院分区：
文献类型：
--
作者：
Koenig, Julie;Linder, Ashley N.;Leutgeb, Stefan
海马旁皮质的网格细胞在跨越整个记录环境的周期性三角形网格的顶点处放电。这种精确的空间神经计算被认为是从细胞内或局部神经回路内同样精确的时间振荡中产生的。我们发现，当大鼠隔内注射利多卡因后θ振荡减少时，内嗅皮层的网格状放电模式消失。其他空间调制的细胞在相同的皮层区域和位置细胞在海马体中保留其空间放电模式在更大程度上在这些期间没有组织良好的振荡神经元活动。因此，在单细胞或局部网络内精确定时的神经活动是周期性空间放电所必需的，而不是单个位置场。
Grid cells in parahippocampal cortices fire at vertices of a periodic triangular grid that spans the entire recording environment. Such precise neural computations in space have been proposed to emerge from equally precise temporal oscillations within cells or within the local neural circuitry. We found that grid-like firing patterns in the entorhinal cortex vanished when theta oscillations were reduced after intraseptal lidocaine infusions in rats. Other spatially modulated cells in the same cortical region and place cells in the hippocampus retained their spatial firing patterns to a larger extent during these periods without well-organized oscillatory neuronal activity. Precisely timed neural activity within single cells or local networks is thus required for periodic spatial firing but not for single place fields.