Frequency response characteristic of sympathetic-mediated vasomotor waves in conscious rats.
Frequency response characteristic of sympathetic-mediated vasomotor waves in conscious rats.
复制标题
清醒大鼠交感神经介导的血管舒缩波的频率响应特征。
DOI：
10.1152/ajpheart.1996.271.4.h1416
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Kregel,KC
中科院分区：
文献类型：
--
作者：
Stauss,HM;Kregel,KC
功率谱分析动脉血压（BP）和心率（HR）已被用于研究自主神经系统的活动。交感神经介导的血管舒缩张力归因于人类和狗在0.05至0.15 Hz频率和大鼠在0.2至0.8 Hz频率之间的血压功率。相比之下，有人认为，狗的交感神经系统过于迟钝，无法传输高于0.017赫兹的频率。因此，我们研究了外周交感神经放电对清醒大鼠外周血管阻力和动脉血压传递的频率响应特性。11只大鼠采用动脉导管、交感内脏神经电极和肠系膜上动脉血流探头。切除离电极近端的内脏神经以避免传入神经受到刺激。第二天，以0.05、0.1、0.2、0.5、1.0和2.0 Hz的频率刺激神经，同时记录有意识大鼠的肠系膜血流量、血压和心率。离线计算肠系膜耐药（MR）。0.05、0.1、0.2、0.5和1.0 Hz的神经刺激显著增加了这些频率下的MR功率。在0.2和0.5 Hz之间发现了最大的反应。MR的这些振荡转化为BP的振荡，而HR没有。当神经退行性变时，第二天的神经刺激没有引起MR或BP的振荡。我们的结论是，大鼠的周围交感神经系统可以以比包括人类在内的一些物种的交感血管舒动活动更高的频率传递信号，甚至可能与呼吸相关的高频范围重叠。
Power spectrum analysis of arterial blood pressure (BP) and heart rate (HR) has been used to investigate autonomic nervous system activity. Sympathetic-mediated vasomotor tone has been attributed to the BP power at frequencies between 0.05 and 0.15 Hz in humans and dogs and between 0.2 and 0.8 Hz in rats. In contrast, it has been suggested that the sympathetic nervous system is too sluggish to transmit frequencies higher than 0.017 Hz in dogs. Thus we investigated the frequency-response characteristics of the transmission of peripheral sympathetic nerve discharge to peripheral vascular resistance and arterial blood pressure in conscious rats. Eleven rats were instrumented with arterial catheters, nerve electrodes on the sympathetic splanchnic nerve, and flow probes on the superior mesenteric artery. The splanchnic nerve was cut proximal to the electrode to avoid afferent nerve stimulation. The next day the nerve was stimulated at frequencies of 0.05, 0.1, 0.2, 0.5, 1.0, and 2.0 Hz while mesenteric blood flow, BP, and HR were recorded in conscious rats. Mesenteric resistance (MR) was calculated off-line. Nerve stimulation at 0.05, 0.1, 0.2, 0.5, and 1.0 Hz significantly increased the power in MR at these respective frequencies. The greatest response was found between 0.2 and 0.5 Hz. These oscillations in MR were translated to oscillations in BP, but not in HR. Nerve stimulation on the second day, when the nerve was degenerated, did not elicit oscillations in MR or BP. We conclude that the peripheral sympathetic nervous system in rats can transmit signals at frequencies higher than those traditionally assigned to sympathetic vasomotor activity in several species, including humans, and may even overlap with the respiration-related high-frequency range.