Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species.
Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species.
复制标题
Roseburia Enteris：从属和种的发现中发现的一种有益肠道生物。
DOI：
10.3389/fcimb.2021.757718
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Nie K;Ma K;Luo W;Shen Z;Yang Z;Xiao M;Tong T;Yang Y;Wang X
肠蔷薇菌是一种厌氧，革兰氏阳性，略带弯曲的杆状鞭毛细菌，在结肠中产生丁酸盐。研究表明，肠球菌通过产生代谢物来预防肠道炎症和维持体内能量平衡。有证据表明，这种细菌会导致多种疾病，如炎症性肠病、2型糖尿病、抗磷脂综合征和动脉粥样硬化。本文综述了肠球菌在人类疾病中的潜在治疗作用。炎症性肠病患者肠球菌的丰度发生了显著变化，针对肠球菌的调节可能会使他们受益匪浅。本文综述的数据表明，肠球菌通过其代谢产物丁酸盐、鞭毛蛋白等调节屏障稳态、免疫细胞和细胞因子释放。近年来在原代培养技术、培养组学、单细胞测序和代谢组学技术的应用方面取得的进展，改善了对玫瑰花菌的研究，并揭示了这种细菌在人类健康和疾病治疗方面的益处。
Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.