Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells.
Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells.
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DOI：
10.1364/ol.35.000700
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发表时间：
2010-03-01
期刊：
影响因子：
3.6
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Zhou C;Tsai TH;Adler DC;Lee HC;Cohen DW;Mondelblatt A;Wang Y;Connolly JL;Fujimoto JG
我们展示了离体高散射人体乳腺组织的光热光学相干断层扫描（OCT）成像。使用 120 kHz 轴向扫描速率、1300 nm 扫频源相敏 OCT 系统来检测由 830 nm 光热激发金纳米壳引起的相变。使用仅 22 mW 的激励功率和高达 20 kHz 的调制频率，在散射组织中 300–600 μm 深处观察到局部相位调制。该技术能够使用纳米壳对癌症标记物进行集成结构和分子靶向成像。
We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300–600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.