Stimulation and Inhibition by Normal Human Serum of Colony Formation in Vitro by Bone Marrow Cells
Stimulation and Inhibition by Normal Human Serum of Colony Formation in Vitro by Bone Marrow Cells
复制标题
正常人血清对骨髓细胞体外集落形成的刺激和抑制
DOI：
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发表时间：
1971
影响因子：
6.5
通讯作者：
E. R. Stanley
中科院分区：
文献类型：
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作者：
S. Chan;D. Metcalf;E. R. Stanley
总结。正常人血清能够刺激小鼠骨髓细胞在体外形成粒细胞和巨噬细胞集落，但只有在通过透析或热处理或乙醚处理去除抑制物质后才能。所有被测试的正常人血清中都存在抑制物，表现出部分的物种特异性，是多种多样的，本质上可能是脂蛋白。这些抑制物在体内的作用尚不清楚，但它们可能调节集落刺激因子(CSF)在刺激粒细胞和巨噬细胞形成方面的作用。
Summary. Normal human sera were able to stimulate granulocyte and macrophage colony formation in vitro by mouse bone marrow cells, but only following removal of inhibitory material either by dialysis or by heat‐ or ether‐treatment. Inhibitors were shown to be present in all normal human sera tested, to exhibit partial species specificity, to be multiple and to be probably lipoprotein in nature. The in vivo function of these inhibitors is unknown but they may modulate the action of the colony stimulating factor (CSF) in stimulating granulopoiesis and macrophage formation.